Observe for wt increase, edema, HTN & excessive K excretion, less obvious signs of adrenocortical steroid untoward effects. Liberal protein intake is essential during prolonged therapy. Reinstitute hormone therapy in any situation of stress after discontinuation of therapy. Ocular herpes simplex. Gradually reduce dose. Aspirin should be used cautiously in conjunction w/ corticosteroids in patients w/ hypoprothrombinemia. Patients w/ nonspecific ulcerative colitis if there is a probability of impending perforation, abscess, or other pyogenic infection. Diverticulitis, fresh intestinal anastomoses, active or latent peptic ulcer, HTN, osteoporosis, acute glomerulonephritis, vaccinia, varicella, exanthema, Cushing's syndrome, antibiotic resistant infections, DM, CHF, chronic nephritis, thromboembolitic tendencies, thrombophlebitis, convulsive disorders, metastatic carcinoma, & myasthenia gravis. Menstrual irregularities may occur in female patients past menarche. Renal insufficiency. Pregnancy, nursing mothers or women of childbearing potential. Carefully observe growth & development of infants & childn. Infants born of mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism.
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